The non-competitive blockade of GABAA receptors by an aqueous extract of water hemlock (Cicuta douglasii) tubers
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- 作者：Benedict T. Greena ; Ben.Green@ars.usda.gov" class="auth_mail" title="E-mail the corresponding author ; Camila Goulartb ; 1 ; Kevin D. Welcha ; James A. Pfistera ; Isabelle McColluma ; Dale R. Gardnera
- 关键词：Water hemlock ; Cicutoxin ; C17-polyacetylenes ; Benzodiazepines ; Barbiturates ; Midazolam
- 刊名：Toxicon
- 出版年：2015
- 出版时间：15 December 2015
- 年：2015
- 卷：108
- 期：Complete
- 页码：11-14
- 全文大小：638 K
文摘
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A Cicuta douglasii extract depressed maximal GABA responses in WSS-1 cells, characteristic of non-competitive antagonism.
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Pretreatment of WSS-1 cells with midazolam reversed the actions of the extract on the WSS-1 cell GABA response.
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The actions of the extract were concentration-dependent.