Effects of γ-hydroxybutyrate on cerebrospinal fluid lactate and glucose levels after spinal cord trauma

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• 作者：Ö ; nder Gü ; ney ; Jale Bengi Celik ; Mehmet Arazi ; Mehmet Erkan Ustun
• 关键词：γ ; -hydroxybutyrate ; spinal cord trauma ; cerebrospinal fluid
• 刊名：Journal of Clinical Neuroscience
• 出版年：2004
• 出版时间：June 2004
• 年：2004
• 卷：11
• 期：5
• 页码：517-520
• 全文大小：120 K

文摘

This study aims to evaluate the effects of γ-hydroxybutyrate (GHB) after spinal cord trauma (SCT). Twenty rabbits were divided equally into four groups: group I was the sham-operated group, group II suffered from SCT but received no treatment, group III was given a dose of 400 mg/kg of GHB intravenously before SCT and group IV received the same dose after SCT. Cerebrospinal fluid (CSF) samples were obtained 30 min before SCT (T₀), at 60 (T₁) and 120 min (T₂) after SCT. There was a threefold increase in lactate levels from baseline value at T₂ in group II, while statistically significant elevation of the lactate levels were not observed in groups III and IV. Glucose levels at T₁ and T₂ were significantly lower in groups III and IV compared with the control group. The findings of this study demonstrate that GHB can control the increase of CSF lactate and glucose levels following SCT and that this metabolic effect may be associated with neuroprotective physiological changes.