Viscoelastic and mechanical behavior of recombinant protein elastomers

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• 作者：Nagapudi ; Karthik ; Brinkman ; William T. ; Thomas ; Benjamin S. ; Park ; Jung O. ; Srinivasarao ; Mohan ; et. al.
• 关键词：Recombinant protein ; Protein polymer ; Triblock copolymer ; Elastin??????mimetic ; Mechanical behavior ; Viscoelastic properties
• 刊名：Biomaterials
• 出版年：2005
• 出版时间：August, 2005
• 年：2005
• 卷：26
• 期：23
• 页码：4695-4706
• 全文大小：495 K

文摘

Recombinant DNA synthesis was employed to produce elastin–mimetic protein triblock copolymers containing chemically distinct midblocks. These materials displayed a broad range of mechanical and viscoelastic responses ranging from plastic to elastic when examined as hydrated gels and films. These properties could be related in a predictable fashion to polymer block size and structure. While these materials could be easily processed into films and gels, electrospinning proved a feasible strategy for creating protein fibers. All told, the range of properties exhibited by this new class of protein triblock copolymer in combination with their easy processability suggests potential utility in a variety of soft prosthetic and tissue engineering applications.