Coronary Artery Disease in French Canadians—Investigation of a Suggested Vulnerable Population

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• 作者：Chadi Ayoub ; MBBS ; FRACP ; FSCCT^a ; ^b ; Jordan Bernick ; MSC^c ; Punitha Arasaratnam ; MBChB ; MRCP^a ; Jonathan D.H. Chow^a ; Alomgir Hossain ; PhD^c ; Terrence Ruddy ; MD ; FRCPC ; FACC^a ; ^d ; Graham S. Hillis ; PhD ; FRCP^b ; ^e ; Leonard Kritharides ; MBBS ; PhD ; FRACP ; FAHA^b ; ^f ; Benjamin J.W. Chow ; MD ; FRCPC ; FACC ; FASNC ; FSCCT^a ; ^f ; ^{bchow@ottawaheart.ca" class="auth_mail" title="E-mail the corresponding author}
• 刊名：Canadian Journal of Cardiology
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：32
• 期：10
• 页码：1240-1245
• 全文大小：358 K

文摘

There is a perception among Canadian physicians that coronary artery disease (CAD) and adverse cardiac events are more common in those of French Canadian heritage. We sought to compare the prevalence of CAD using coronary computed tomographic angiography (CCTA) in French Canadians and non-French white Canadians.

Methods

Consecutive patients were prospectively enrolled in our institutional CCTA registry. Of 10,868 CCTA examinations, we analyzed white patients who identified themselves as French Canadian or non-French Canadian. These 2 groups were compared for baseline characteristics, cardiovascular risk factors, and routine markers for CAD on CTCA. Propensity score adjustments were also made to account for differences in demographics.

Results

We identified 1683 French Canadians (mean age, 58.5 ± 10.7 years; 54.2% men) and 5077 non-French white Canadians (mean age, 59.4 ± 11.4 years; 57.3% men). French Canadians were more likely to have a smoking history (64.1% vs 56.1%), diabetes (15.6% vs 13.6%), and a family history of premature CAD (53.3% vs 44.6%) (P < 0.05 for all). There was no significant difference in measures of CAD between French Canadians and non-French white Canadians in obstructive CAD (32.5% vs 32.2%; P = 0.997), total plaque score (4.6 ± 4.3 vs 4.5 ± 4.4; P = 0.616) and Agatston score (168.1 ± 319.8 vs 183.6 ± 433.7; P = 0.371). After propensity score adjustment, there was still no significant difference between the groups.

Conclusions

Our study suggests that French Canadians in the Champlain region have a greater prevalence of cardiovascular risk factors compared with non-French Canadians; however, they do not appear to have a greater prevalence or severity of coronary atherosclerosis as assessed by CCTA.