Two cellular hypotheses explaining the initiation of ketamine's antidepressant actions: Direct inhibition and disinhibition
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- 作者：Oliver H. Miller omiller1@tulane.edu" class="auth_mail" title="E-mail the corresponding author ; Jacqueline T. Moran jmoran4@tulane.edu" class="auth_mail" title="E-mail the corresponding author ; Benjamin J. Hall ; benjamin.hall@roche.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Ketamine ; Depression ; NMDAR ; GluN2B ; AMPAR ; Ambient glutamate ; Cortex ; Inhibition ; Disinhibition ; NMDA receptor ; AMPA receptor ; Homeostatic synaptic plasticity ; Protein synthesis
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：100
- 期：Complete
- 页码：17-26
- 全文大小：1303 K
文摘
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Low dose ketamine produces antidepressant actions in MDD and TRD patients.
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The cellular mechanisms underlying ketamine's antidepressant actions remain unclear.
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Two mechanistic hypotheses to explain how ketamine's actions are initiated are reviewed here.
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These two hypotheses offer a framework for studying ketamine's effects as an anti-depressant.