Adolescent chronic stress causes hypothalamo-pituitary-adrenocortical hypo-responsiveness and depression-like behavior in adult female rats
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- 作者：Aynara C. Wulsina ; b ; Dayna Wick-Carlsona ; Benjamin A. Packarda ; Rachel Moranoa ; James P. Hermana ; b ; james.herman@uc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Adolescence ; Chronic variable stress ; Neuroendocrine ; Depression ; Female rodent
- 刊名：Psychoneuroendocrinology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：65
- 期：Complete
- 页码：109-117
- 全文大小：1484 K
文摘
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Studied the neuroendocrine and behavioral effects of adolescent CVS exposure.
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Exposure to CVS in adolescence blunts HPA axis response in adult female rats.
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CVS in adolescents leads to depressive-like behaviors in adult female rats.
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Adolescent rats exposed to CVS do not show deficits in stress or emotional reactivity.
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Stress exposure in adolescence may alter the developmental trajectory of stress circuits.