Divergent effects of repeated restraint versus chronic variable stress on prefrontal cortical immune status after LPS injection
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- 作者：Brittany L. Smith ; smith5bl@mail.uc.edu" class="auth_mail" title="E-mail the corresponding author ; Sarah N. Schmeltzer ; Benjamin A. Packard ; Renu Sah ; James P. Herman
- 关键词：Chronic stress ; Prefrontal cortex ; Microglia ; LPS ; Cytokines
- 刊名：Brain, Behavior, and Immunity
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：57
- 期：Complete
- 页码：263-270
- 全文大小：1213 K
文摘
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Repeated restraint increases PFC Iba-1 soma size with subsequent LPS injection.
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CVS decreases PFC proinflammatory cytokine gene expression despite LPS injection.
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PFC immune responses are highly dependent on chronic stress modality.