Novel approaches to whole sporozoite vaccination against malaria

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• 作者：Else M. Bijker^a ; ^{else.bijker@radboudumc.nl" class="auth_mail" title="E-mail the corresponding author} ; Steffen Borrmann^b ; ^c ; ^d ; Stefan H. Kappe^e ; ^f ; Benjamin Mordm&uuml ; ller^b ; ^c ; ^g ; Brandon K. Sack^e ; Shahid M. Khan^h
• 关键词：Malaria ; Plasmodium ; Vaccine ; Immunization ; Sporozoite ; Chemoprophylaxis ; Chloroquine ; Genetic attenuation ; Liver stage ; Pre-erythrocytic stages
• 刊名：Vaccine
• 出版年：2015
• 出版时间：22 December 2015
• 年：2015
• 卷：33
• 期：52
• 页码：7462-7468
• 全文大小：868 K

文摘

The parasitic disease malaria threatens more than 3 billion people worldwide, resulting in more than 200 million clinical cases and almost 600,000 deaths annually. Vaccines remain crucial for prevention and ultimately eradication of infectious diseases and, for malaria, whole sporozoite based immunization has been shown to be the most effective in experimental settings. In addition to immunization with radiation-attenuated sporozoites, chemoprophylaxis and sporozoites (CPS) is a highly efficient strategy to induce sterile protection in humans. Genetically attenuated parasites (GAP) have demonstrated significant protection in rodent studies, and are now being advanced into clinical testing. This review describes the existing pre-clinical and clinical data on CPS and GAP, discusses recent developments and examines how to transform these immunization approaches into vaccine candidates for clinical development.