Anterior cingulate GABA levels predict whole-brain cerebral blood flow

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• 作者：Benjamin W. Krause ; S. Andrea Wijtenburg ; Henry H. Holcomb ; Peter Kochunov ; Danny J.J. Wang ; L. Elliot Hong ; Laura M. Rowl
• 关键词：Arterial spin labeling ; Cerebral blood flow ; GABA ; Magnetic resonance spectroscopy ; Anterior cingulate
• 刊名：Neuroscience Letters
• 出版年：21 February, 2014
• 年：2014
• 卷：561
• 期：Complete
• 页码：188-191
• 全文大小：775 K

文摘

This study examined the relationship of 纬-aminobutyric acid (GABA) and glutamate levels from the anterior and posterior cingulates (AC and PC) with cerebral blood flow (CBF) at rest. ¹H magnetic resonance spectroscopy measurements in the AC and PC and pseudo-continuous arterial spin labeling data were acquired from 10 healthy controls. GABA levels from the AC were strongly inversely correlated with global (whole-brain) CBF (r = 鈭?.91, p = 0.0015). GABA levels from the PC and glutamate levels from both regions were not significantly correlated with CBF. We hypothesize that GABA-mediated inhibition of AC activation of the locus coeruleus-norepinephrine pathway may influence global CBF.