Recapitulation of treatment response patterns in a novel humanized mouse model for chronic hepatitis B virus infection

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• 作者：Benjamin Y. Winer^a ; Tiffany Huang^a ; Benjamin E. Low^b ; Cindy Avery^b ; Mihai-Alexandru Pais^a ; Gabriela Hrebikova^a ; Evelyn Siu^a ; Luis Chiriboga^c ; Michael V. Wiles^b ; Alexander Ploss^a ; ^{aploss@princeton.edu}
• 关键词：Hepatitis B virus (HBV) ; Humanized mice ; Antivirals ; Genome engineering
• 刊名：Virology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：502
• 期：Complete
• 页码：63-72
• 全文大小：1633 K
• 卷排序：502

文摘

Targeted gene disruption on complex genetic backgrounds. Robust engraftment of human hepatocytes in novel xenorecipient strain. Persistent HBV viremia in human liver chimeric mice. Viral suppression upon HBV treatment. Potential utility for anti-HBV drug testing.