Cytotoxic, anti-proliferative and antimicrobial furanoditerpenoids from Stuhlmania moavi
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- 作者：Josiah O. Odalo ; Cosam C. Joseph ; Mayunga H.H. Nkunya ; Isabel Sattler ; Corina Lange ; Hans-Martin Dahse ; Ute Mö ; llman
- 关键词：Stuhlmania moavi ; Ceasalpiniaceae ; Furanoditerpenoids ; Anti-proliferative ; Antimicrobial ; Cytotoxic
- 刊名：Phytochemistry
- 出版年：2009
- 出版时间：December 2009
- 年：2009
- 卷：70
- 期：17-18
- 页码：2047-2052
- 全文大小：315 K
文摘
The furanoditerpenoids voucapane, voucapane-6α,7α-diol, voucapane-18,19-diol and 18-hydroxyvoucapan-19-al were isolated from the cytotoxic stem and root bark extracts of Stuhlmania moavi Verdc. (Ceasalpiniaceae) and their structures established based on analysis of spectroscopic data. The compounds exhibited anti-proliferative, cytotoxic, antibacterial and antifungal activities, 18-hydroxyvoucapan-19-al showing the highest anti-proliferative and cytotoxic properties. Voucapane-18,19-diol was only mildly active but the activity was enhanced for its 18,19-di-(4-methyl)-benzenesulphonate. Some of these results thus corroborate the traditional medicinal uses of the crude extracts for the treatment of skin infections.