The synthesis and biological evaluation of a series of novel 2-COOC₂H₅/COONa substituted 1,5-benzothiazepine derivatives as antimicrobial agents

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• 作者：Ping Zhang ; Lan Zhi Wang ; Hui Shu Wu ; Jia Ming Lan ; Yuan Li ; Yong Xiang Wang
• 关键词：1 ; 5-Benzothiazepine ; Antifungal ; Antibacterial activities
• 刊名：Chinese Chemical Letters
• 出版年：2009
• 出版时间：June 2009
• 年：2009
• 卷：20
• 期：6
• 页码：660-662
• 全文大小：128 K

文摘

A series of novel 1,5-benzothiazepine derivatives containing COOC₂H₅/COONa groups at the C(2)-position were synthesized and evaluated for their antifungal and antibacterial activities by both disc diffusion and minimal inhibition concentration (MIC) methods. Most of the compounds have been shown to have moderate to good antibacterial activity against S. aureus, S. epidermidis and excellent antifungal activity against C. albicans.