Design, synthesis and biological activity evaluation of novel 2,6-difluorobenzamide derivatives through FtsZ inhibition

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• 作者：Fangchao Bi^a ; ¹ ; Liwei Guo^a ; ¹ ; Yinhu Wang^a ; Henrietta Venter^b ; Susan J. Semple^b ; Fang Liu^a ; Shutao Ma^a ; ^{mashutao@sdu.edu.cn}
• 关键词：Benzamide derivatives ; Design and synthesis ; FtsZ inhibition ; Biological activity
• 刊名：Bioorganic & Medicinal Chemistry Letters
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：27
• 期：4
• 页码：958-962
• 全文大小：1023 K
• 卷排序：27

文摘

Novel 2,6-difluorobenzamide derivatives were synthesized and evaluated. Some compounds showed potent activity against both susceptible and resistant strains. They exerted their effects by inhibition of bacterial cell division protein FtsZ. Replacing the benzothiazole with benzimidazole lost its antibacterial activity.