Sesquiterpenes from the roots of Lindera strychnifolia with inhibitory effects on nitric oxide production in RAW 264.7 cells

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• 作者：Qing Liu ; Yang Hee Jo ; Seon Beom Kim ; Qinghao Jin ; Bang Yeon Hwang ; Mi Kyeong Lee ; ^{mklee@chungbuk.ac.kr" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Lindera strychnifolia ; Lauraceae ; Sesquiterpene ; Linderolides N&ndash ; T ; Anti-inflammation
• 刊名：Bioorganic & Medicinal Chemistry Letters
• 出版年：2016
• 出版时间：15 October 2016
• 年：2016
• 卷：26
• 期：20
• 页码：4950-4954
• 全文大小：669 K

文摘

Seven new sesquiterpenes, linderolides N–T (1–7), along with nine known compounds, were isolated from roots of Lindera strychnifolia (Lauraceae). Their structures were established by extensive spectroscopic analysis. The relative and absolute configurations were determined by NOESY and CD analysis, respectively. Among the isolated compounds, two new compounds, linderolide O (2) and linderolide P (3) inhibited lipopolysaccharide-stimulated nitric oxide production in murine RAW 264.7 macrophage cells, with IC₅₀ values of 6.3 and 9.6 μM, respectively.