H3S10 phosphorylation-mediated transcriptional regulation by Aurora kinase A
详细信息 查看全文
- 作者：Se-Ryeon Kim ; Kee-Beom Kim ; Yun-Cheol Chae ; Jin Woo Park ; Sang-Beom Seo ; sangbs@cau.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Aurora kinase A ; H3S10 phosphorylation ; Transcription ; G9a ; Leukemia cell differentiation
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：469
- 期：1
- 页码：22-28
- 全文大小：1200 K
文摘
- •
AURKA phosphorylates H3S10 and activates target gene transcription.
- •
AURKA is recruited to target gene promoters and activates transcription via H3S10 phosphorylation.
- •
Recruitment of AURKA is disrupted by inhibitor Alisertib and results in G9a-mediated H3K9-me2.