Antihistaminic and anticholinergic activity of barberry fruit (Berberis vulgaris) in the guinea-pig ileum

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• 作者：Shamsa ; F. ; Ahmadiani ; A. ; Khosrokhavar ; R.
• 关键词：Barberry ; Antihistaminic ; Anticholinergic ; Guinea-pig ileum
• 刊名：Journal of Ethnopharmacology
• 出版年：1999
• 出版时间：February 1, 1999
• 年：1999
• 卷：64
• 期：2
• 页码：161-166
• 全文大小：101 K

文摘

Barberry (Berberis vulgaris) is a well known medicinal plant in Iran and has also been used as food. The antihistaminic and anticholinergic activity of aqueous extract of barberry fruits were investigated on isolated guinea-pig ileum, and dose–response curves of histamine and acetylcholine with and without extract were plotted. The pA₂ values for antihistaminic activity of extract and dexchlorpheniramine were calculated (extract; pA₂±S.E.M.=4.50±0.01[−log C (g/l)]; dexchlorpheniramine; pA₂±S.E.M.=9.36±0.14[−log C (M)]) and compared with each other. The pA₂ values for anticholinergic activity of extract and atropine were also calculated (extract, pA₂±S.E.M.=4.37±0.03[−log C (g/l)]; atropine, pA₂± S.E.M.=8.99±0.13[−log C (M)]) and compared. The results indicated antihistaminic and anticholinergic activity of extract that seems to be of the competitive type.