Ascites and malnutrition are predictive factors for incomplete cytoreductive surgery for peritoneal carcinomatosis from gastric cancer

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• 作者：Emmanuel I. Benizri ; M.D. ; Ph.D. ; ^{benizri.e@chu-nice.fr} ; Jean-Marc Bereder ; M.D. ; Amine Rahili ; M.D. ; Jean-Louis Bernard ; M.D. ; Daniel Benchimol ; M.D.
• 关键词：Gastric cancer ; Peritoneal carcinomatosis ; Cytoreductive surgery ; Intraperitoneal chemotherapy
• 刊名：The American Journal of Surgery
• 出版年：2013
• 出版时间：June, 2013
• 年：2013
• 卷：205
• 期：6
• 页码：668-673
• 全文大小：351 K

文摘

Background

Prognosis in peritoneal carcinomatosis from gastric cancer has improved with cytoreductive surgery (CS) and hyperthermic intraperitoneal chemotherapy. The aim of this study was to identify predictive factors for incomplete CS.

Methods

Forty-five patients undergoing laparotomy for gastric cancer with peritoneal carcinomatosis were prospectively included from January 2000 to December 2010. In case of optimal CS, patients (n = 14) received hyperthermic intraperitoneal chemotherapy. Otherwise, the laparotomy was closed or a palliative procedure was performed if necessary. All preoperative data were compared between the 2?groups.

Results

Ascites (hazard ratio, .09; 95 % confidence interval, .010-.48; m>Pm> = .0103) and nutritional status evaluated by the prognostic nutrition index (hazard ratio, .11; 95 % confidence interval, .0019-.54; m>Pm> = .027) were independent predictive factors for incomplete CS.

Conclusions

The selection of patients for CS plus hyperthermic intraperitoneal chemotherapy should include the assessment of nutritional status and the detection of an ascites.