A male and female RNA marker to infer sex in forensic analysis

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• 作者：M. van den Berge ^{m.van.den.berge@nfi.minvenj.nl} ; T. Sijen ; ^{t.sijen@nfi.minvenj.nl}
• 关键词：Forensic science ; mRNA profiling ; Body fluid identification ; Organ tissue identification ; Sex-specific RNA marker ; Sex-biased genes
• 刊名：Forensic Science International: Genetics
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：26
• 期：Complete
• 页码：70-76
• 全文大小：1237 K
• 卷排序：26

文摘

Two sex-biased genes are found suitable to infer sex in RNA assays. XIST is female-expressed from its function in X-chromosome inactivation. RPS4Y1 is Y-chromosome-specific and therefore male-expressed. Both markers are incorporated in two multiplexes targeting body fluids or organs. These assays were validated for casework.