Helicobacter pylori primary resistant strains over 11 years in French children

详细信息    查看全文

• 作者：Nicolas Kalach ; Lydia Serhal ; Edgar Asmar ; Florence Campeotto ; Michel Bergeret ; Eric Dehecq ; Claire Spyckerelle ; Marie-Laure Charkaluk ; Anne Decoster ; Christophe Dupont ; Josette Raymond
• 关键词：Helicobacter pylori ; Antimicrobial resistance ; Clarithromycin ; Metronidazole ; Children
• 刊名：Diagnostic Microbiology and Infectious Disease
• 出版年：2007
• 出版时间：October 2007
• 年：2007
• 卷：59
• 期：2
• 页码：217-222
• 全文大小：218 K

文摘

The yearly prevalence between 1994 and 2005 of primary resistance to amoxicillin, metronidazole, and clarithromycin of 377 Helicobacter pylori strains isolated from children was studied. All the H. pylori strains were susceptible to amoxicillin, 138/377 (36.7 % ) were resistant to metronidazole, 86/377 (22.8 % ) to clarithromycin, and 30/377 (7.9 % ) to both metronidazole and clarithromycin. Over the entire period, resistance to clarithromycin did not change, whereas metronidazole resistance decreased significantly from 43.3 % (1994–1998) to 32 % (1999–2005), P = 0.001.