Enhanced insulin sensitivity in skeletal muscle and liver by physiological overexpression of SIRT6
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- 作者：Jason G. Anderson1 ; 7 ; Giorgio Ramadori1 ; 2 ; 3 ; 7 ; Rafael M. Ioris2 ; 3 ; 7 ; Mirco Galiè ; 2 ; Eric D. Berglund4 ; 5 ; Katie C. Coate5 ; Teppei Fujikawa1 ; Stefania Pucciarelli6 ; Benedetta Moreschini6 ; Augusto Amici6 ; Cristina Andreani6 ; Roberto Coppari1 ; 2 ; 3 ; roberto.coppari@unige.ch" class="auth_mail" title="E-mail the corresponding author
- 关键词：SIRT6 overexpression ; Sirtuin ; Insulin sensitivity ; Glucose homeostasis ; Diabetes
- 刊名：Molecular Metabolism
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：4
- 期：11
- 页码：846-856
- 全文大小：2201 K
文摘
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“Sirt6BAC” mice overexpress SIRT6 in a physiological manner unattained previously.
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SIRT6 overexpression protects against aberrant glucose homeostasis.
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Sirt6BAC mice exhibit enhanced insulin sensitivity in skeletal muscle and liver.
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Pharmacologically enhancing SIRT6 activity may be a viable way to treat diabetes.