Outcome of unexpected adnexal neoplasia discovered during risk reduction salpingo-oophorectomy in women with germ-line BRCA1 or BRCA2 mutations

详细信息    查看全文

• 作者：James R. Conner ; Emily Meserve ; Ellen Pizer ; Judy Garber ; Michael Roh ; Nicole Urban ; Charles Drescher ; Bradley J. Quade ; Michael Muto ; Brooke E. Howitt ; Mark D. Pearlman ; Ross S. Berkowitz ; Neil Horowitz ; Christopher P. Crum ; Colleen Feltmate
• 关键词：BRCA ; Fallopian ; Ovarian cancer ; Serous cancer
• 刊名：Gynecologic Oncology
• 出版年：February, 2014
• 年：2014
• 卷：132
• 期：2
• 页码：280-286
• 全文大小：386 K

文摘

Objective

This study computed the risk of clinically silent adnexal neoplasia in women with germ-line BRCA1 or BRCA2 mutations (BRCA^m +) and determined recurrence risk.

Methods

We analyzed risk reduction salpingo-oophorectomies (RRSOs) from 349 BRCA^m + women processed by the SEE-FIM protocol and addressed recurrence rates for 29 neoplasms from three institutions.

Results

Nineteen neoplasms (5.4%) were identified at one institution, 9.2% of BRCA1 and 3.4% of BRCA2 mutation-positive women. Fourteen had a high-grade tubal intraepithelial neoplasm (HGTIN, 74%). Mean age (54.4) was higher than the BRCA^m + cohort without neoplasia (47.8) and frequency increased with age (p < 0.001). Twenty-nine BRCA^m + patients with neoplasia from three institutions were followed for a median of 5 years (1-8 years.). One of 11 with HGTIN alone (9%) recurred at 4 years, in contrast to 3 of 18 with invasion or involvement of other sites (16.7%). All but two are currently alive. Among the 29 patients in the three institution cohort, mean ages for HGTIN and advanced disease were 49.2 and 57.7 (p = 0.027).

Conclusions

Adnexal neoplasia is present in 5-6% of RRSOs, is more common in women with BRCA1 mutations, and recurs in 9% of women with HGTIN alone. The lag in time from diagnosis of the HGTIN to pelvic recurrence (4 years) and differences in mean age between HGTIN and advanced disease (8.5 years) suggest an interval of several years from the onset of HGTIN until pelvic cancer develops. However, some neoplasms occur in the absence of HGTIN.