Protein sorting gone wrong - VPS10P domain receptors in cardiovascular and metabolic diseases
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- 作者：Vanessa Schmidt ; vanessa.schmidt@mdc-berlin.de" class="auth_mail" title="E-mail the corresponding author ; Thomas E. Willnow ; willnow@mdc-berlin.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Protein sorting ; VPS10P domain receptors ; Lipoprotein receptors ; GWAS ; Risk genes ; Cholesterol metabolism ; Mouse models
- 刊名：Atherosclerosis
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：245
- 期：Complete
- 页码：194-199
- 全文大小：878 K
文摘
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GWAS implicated several VPS10P domain receptors in cardiovascular and metabolic diseases.
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SORLA promotes atherosclerosis by facilitation of smooth muscle cell migration in the vessel wall.
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SORLA is also a clearance receptor for apoA-V, regulating lipolysis of triglyceride-rich lipoproteins.
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Sortilin controls hepatic lipoprotein metabolism and PCSK9 action.
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SORCS1 is a risk factor for diabetes modulating insulin secretion from pancreatic islets.