PCC characteristics at rest in 10-year memory decliners

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• 作者：Charlotte Bernard^a ; ^b ; ^c ; ^{charlotte.bernard1@yahoo.fr" class="auth_mail" title="E-mail the corresponding author} ; Bixente Dilharreguy^a ; ^b ; Catherine Helmer^d ; ^e ; ^f ; Sandra Chanraud^a ; ^b ; ^c ; Hé ; lè ; ne Amieva^d ; ^e ; Jean-Franç ; ois Dartigues^d ; ^e ; ^g ; Michè ; le Allard^a ; ^b ; ^c ; Gwé ; naë ; lle Catheline^a ; ^b ; ^c
• 关键词：Resting-state fMRI ; NBS ; Graph theory ; Aging ; Memory decline ; PCC
• 刊名：Neurobiology of Aging
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：36
• 期：10
• 页码：2812-2820
• 全文大小：1129 K

文摘

The present research sought to characterize the intrinsic functional networks associated with a 10-year episodic memory decline in elderly using data from a longitudinal population-based cohort (Bordeaux-3City). Complementary measures of whole-brain resting-state functional magnetic resonance imaging investigations were combined to compare functional architecture of brain networks both at connectional and topological levels in 22 decliners to 22 nondecliners; episodic memory decline being assessed through a multiple time point Free and Cued Selective Reminding Test. The decliners presented differences in functional architecture centered on the posterior cingulate cortex, characterized by a significant decrease of connectivity intensity, a significant increased centrality. In accordance, a decrease of the functional connectivity inside the default mode network was observed in the decliners. Our results highlight the central role of the posterior cingulate cortex in a slow but reliable memory decline in elderly. Because functional alterations of this region are currently described in Alzheimer's disease, this functional signature could constitute a risk for Alzheimer's disease.