Leoligin, the major lignan from Edelweiss, inhibits 3-hydroxy-3-methyl-glutaryl-CoA reductase and reduces cholesterol levels in ApoE −/− mice
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- 作者：Bernhard Scharingera ; Barbara Messnera ; Adrian Tü ; rkcana ; Daniela Schusterb ; Anna Vuorinenb ; Florian Pitterlc ; Katharina Heinzd ; Kathrin Arnhardc ; Gü ; nther Laufere ; Michael Grimmd ; Hermann Stuppnerf ; Herbert Oberacherc ; Philipp Ellerg ; Andreas Ritschh ; David Bernhardd ; david.bernhard@i-med.ac.at" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cholesterol ; HMGCR inhibitor ; Diabetes ; Obesity ; Therapy
- 刊名：Journal of Molecular and Cellular Cardiology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：99
- 期：Complete
- 页码：35-46
- 全文大小：2209 K
文摘
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Leoligin reduces LDL cholesterol levels and improves LDL/HDL and LDL/total cholesterol ratios.
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Leoligin's beneficial effects on cholesterol levels can be explained by its HMG-CoA reductase inhibitory activity.
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In silico modelling suggest an unconventional interaction of Leoligin with HMG-CoA-reductase.
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Leoligin reduces peak glucose levels in glucose tolerance test and reduces weight gain.