Clinical evaluation of pimecrolimus eye drops for treatment of canine keratoconjunctivitis sicca: A comparison with cyclosporine A

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• 作者：Ron Ofri ; George N. Lambrou ; Ingrid Allgoewer ; Uwe Graenitz ; Teresa M. Pena ; Bernhard M. Spiess ; Elisabeth Latour
• 关键词：Dog ; Keratoconjunctivitis sicca ; Dry eye ; Cyclosporine A ; Pimecrolimus
• 刊名：The Veterinary Journal
• 出版年：2009
• 出版时间：January 2009
• 年：2009
• 卷：179
• 期：1
• 页码：70-77
• 全文大小：231 K

文摘

The aim of this study was to evaluate the efficacy of pimecrolimus oil-based eye drops in alleviating the clinical signs of keratoconjunctivitis sicca (KCS) in dogs and to compare the efficacy with that of cyclosporine A (CsA) ointment. An open-label, multicenter study enrolling 44 dogs previously untreated with CsA was conducted. Dogs were randomly assigned to a treatment group and medicated twice daily for 8 weeks. After that time the mean increase (±SEM) in the Schirmer tear test was 9.2 ± 1.6 mm/min in the pimecrolimus group and 5.8 ± 1.1 mm/min in the CsA group (P = 0.085). The improvement in clinical signs of inflammation in eyes treated with pimecrolimus was significantly greater than in eyes treated with CsA (P = 0.02). The results show that 1 % pimecrolimus oily eye drops are as safe as and more effective than CsA ointment in controlling KCS in dogs.