- 作者：Carlo Campagnoli ; Franco Berrino ; Elisabetta Venturelli ; Chiara Abb脿 ; Nicoletta Biglia ; Tiziana Brucato ; Patrizia Cogliati ; Saverio Danese ; Michela Donadio ; Gianna Zito ; Patrizia Pasanisi
- 关键词：Dehydroepiandrosterone sulfate ; Estradiol ; IGF1 ; Randomized trial ; Testosterone
- 刊名：Clinical Breast Cancer
- 出版年：December, 2013
- 年：2013
- 卷：13
- 期：6
- 页码：433-438
- 全文大小：149 K
lass="h4">Introduction
Diabetic patients treated with metformin have a lower risk of developing BC or a better BC prognosis. Metformin might reduce cancer growth through direct antiproliferative effects or through indirect mechanisms, particularly the reduction of insulin. In a randomized study on nondiabetic BC patients in natural menopause with high聽testosterone levels, we observed a significant decrease in insulin and in testosterone levels with metformin 1500聽mg/d compared with 1000 mg/d. We present the results of a new analysis of our study on the effect of metformin on the bioavailability of sex hormones.lass="h4">Patients and Methods
One hundred twenty-four eligible women were initially聽invited to take metformin 500 mg/d for 3 months. The 108 women who completed the first 3 months continued the study using 1000 mg/d for 1 month. The women were then randomized into 2 groups, and, for the subsequent 5聽months, 1 group increased the dose to 1500 mg/d, and the other group continued with 1000 mg/d.
lass="h4">Results
Ninety-six women completed the study, 43 receiving metformin 1500 mg/day, and 53 receiving 1000 mg/day. The women receiving 1500 mg/d showed a greater and significant reduction of free testosterone (鈭?9%) and estradiol (鈭?8%), a borderline significant reduction of estrone and insulin-like growth factor-1, and a nonsignificant reduction of androstenedione. They also showed a nonsignificant increase of dehydroepiandrosterone sulfate.
lass="h4">Conclusion
Metformin does not interfere with the production of dehydroepiandrosterone sulfate. Besides, it decreases estradiol levels, basically through the reduction of testosterone. These hormonal changes might have clinical relevance.