The accelerated development of an optimized synthesis of 1,2,4-oxadiazoles: application of microwave irradiation and statistical design of experiments

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• 作者：Evans ; Marc D. ; Ring ; Jessica ; Schoen ; Adam ; Bell ; Andrew ; Edwards ; Paul ; Berthelot ; Didier ; et. al.
• 关键词：oxadiazole ; microwave ; design of experiments ; amidoxime ; optimization
• 刊名：Tetrahedron Letters
• 出版年：2003
• 出版时间：December 22, 2003
• 年：2003
• 卷：44
• 期：5
• 页码：9337-9341
• 全文大小：269 K

文摘

Herein, we report the development of an optimized microwave-assisted synthesis of 1,2,4-oxadiazoles. The chemistry development process was significantly accelerated by employing a statistical software package (MODDE 6.0™) to guide in the optimization of the reaction conditions. The resulting optimized reaction conditions were then utilized in the synthesis of a focused library of 1,2,4-oxadiazoles.