Time-dependent effects of treadmill exercise on aversive memory and cyclooxygenase pathway function

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• 作者：Gisele Agustini Lovatel ; Karine Bertoldi ; Viviane Rostirola Elsner ; Cl¨¢udia Vanzella ; Felipe dos Santos Moys¨¦s ; Christiano Spindler ; Vinicius Rafael Funck ; Leticia Meier Pereira ; Clarissa Vasconcelos de Oliveira ; Mauro Schneider Oliveira ; Carlos Alex ; re Netto ; Ionara Rodrigues Siqueira
• 关键词：Physical exercise ; Cyclooxygenase-2 ; Prostaglandin E2 ; E-prostanoid receptors ; Hippocampus ; Rat
• 刊名：Neurobiology of Learning and Memory
• 出版年：2012
• 出版时间：September, 2012
• 年：2012
• 卷：98
• 期：2
• 页码：182-187
• 全文大小：505 K

文摘

Exercise induces brain function adaptations and improves learning and memory; however the time window of exercise effects has been poorly investigated. Studies demonstrate an important role for cyclooxygenase-2 (COX-2) pathway function in the mechanisms underlying memory formation. The aim of present work was to investigate the effects of treadmill exercise on aversive memory and COX-2, PGE₂ and E-prostanoid receptors contents in the rat hippocampus at different time points after exercise has ended. Adult male Wistar rats were assigned to non-exercised (sedentary) and exercised (running daily for 20 min, for 2 weeks) groups. The inhibitory avoidance task was used to assess aversive memory and the COX-2, PGE₂ and E-prostanoid receptors (EP1, EP2, EP3 and EP4) levels were determined 1 h, 18 h, 3 days or 7 days after the last training session of treadmill exercise. The step down latency in the inhibitory avoidance, COX-2 and EP4 receptors levels were acutely increased by exercise, with a significant positive correlation between aversive memory performance and COX-2 levels. Increased EP2 content decreased PGE₂ levels were observed 7 days after the last running session. The treadmill exercise protocol facilitates inhibitory avoidance memory and induces time-dependent changes on COX-2 pathways function (COX-2, PGE₂ and EP receptors).