8-Hydroxy-2'-Deoxyguanosine and Lipid Peroxidation in Patients With Heart Failure

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• 作者：Miguel Rivera ; Esther Roselló ; -Llet&#xed ; Fern ; o Garc&#xed ; a de Burgos ; Vicente Bertomeu ; Rafael Payá ; Raquel Corté ; s ; Luis Mart&#xed ; nez-Dolz ; Alej ; ro Jordá ; n ; Jose L. Pé ; rez-Boscá ; Antonio Salvador ; Francisco Mar&#xed ; n ; Francisco Sogorb ; Ricardo Valero ; Vicente Miró
• 关键词：Oxidative stress ; Heart failure ; Free radicals
• 刊名：Revista Española de Cardiología (English Edition)
• 出版年：2006
• 出版时间：2006
• 年：2006
• 卷：59
• 期：11
• 页码：1140-1145
• 全文大小：88 K

文摘

Introduction and objectives

Heart failure is associated with increased free radical production, which leads to a state of oxidative stress. Known markers of oxidative stress include 8-hydroxy-2'-deoxyguanosine, which reflects oxidative damage to DNA, and lipid peroxidation, which can be used to quantify damage to lipid-rich structures. The aims of this study were to compare 8-hydroxy-2'-deoxyguanosine and lipid peroxidation levels in heart failure patients and healthy subjects and to assess how these levels are influenced by heart failure etiology.

Methods

The study included 78 patients (57 male, age 64 [14] years) with heart failure and 12 control subjects. Patients completed a questionnaire and were graded according to the New York Heart Association classification. Doppler echocardiography was performed and blood samples were obtained. 8-hydroxy-2'-deoxyguanosine and lipid peroxidation levels were determined.

Results

Significant differences were observed between patients and control subjects in 8-hydroxy-2'-deoxyguanosine and lipid peroxidation levels, at 0.34 (0.54) ng/mL vs 0.04 (0.07) ng/mL (P<.05), and 18 (10) μM vs 8 (3) μM (P<.01), respectively. Subsequent analysis showed that heart failure etiology had a significant effect on the levels of the two markers (P<.05), which were highest in patients with hypertensive cardiomyopathy.

Conclusions

Levels of 8-hydroxy-2'-deoxyguanosine and lipid peroxidation were higher in heart failure patients than in control subjects. The most significant increases were found in patients with hypertensive cardiomyopathy.