Auxiliary GABAB Receptor Subunits Uncouple G Protein 尾纬 Subunits from Effector Channels to Induce Desensitization
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- 作者：Rostislav Turecek1 ; 2 ; Jochen Schwenk3 ; 4 ; Thorsten Fritzius1 ; Klara Ivankova1 ; Gerd Zolles3 ; Lisa Adelfinger1 ; Valerie Jacquier1 ; Valerie Besseyrias1 ; Martin Gassmann1 ; Uwe Schulte3 ; 4 ; Bernd Fakler3 ; 4 ; bernd.fakler@physiologie.uni-freiburg.de" class="auth_mail ; Bernhard Bettler1 ; bernhard.bettler@unibas.ch" class="auth_mail
- 刊名：Neuron
- 出版年：4 June 2014
- 年：2014
- 卷：82
- 期：5
- 页码：1032-1044
- 全文大小：1620 K
文摘
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KCTD8, KCTD12, and KCTD16 proteins bind to G protein 尾纬 subunits
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KCTD12 uncouples 尾纬 subunits from K+ channels to desensitize the current response
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KCTD12 protein in the brain is exclusively associated with GABAB receptors
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GABAB receptors produce receptor-specific desensitization by harnessing KCTD12