Calcipotriol and betamethasone dipropionate exert additive inhibitory effects on the cytokine expression of inflammatory dendritic cell-Th17 cell axis in psoriasis
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- 作者：Paola Lovatoa ; paola.lovato@leo-pharma.com" class="auth_mail" title="E-mail the corresponding author ; Hanne Norsgaarda ; Yoshiki Tokurac ; Mads A. Rø ; pkeb
- 关键词：ELISA ; enzyme-linked immunosorbent assay ; VDR ; vitamin D receptor ; Tc cell ; T cytotoxic cell ; Th cell ; T helper cell ; Treg cell ; T regulatory cell ; Tcm ; central memory T cells ; Tem ; effector memory T cells ; RORC ; RAR-related orphan receptor C ; GATA3 ; GATA binding protein 3 ; FOXP3 ; forkhead box P3
- 刊名：Journal of Dermatological Science
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：81
- 期：3
- 页码：153-164
- 全文大小：2492 K
文摘
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Calcipotriol significantly adds to the anti-inflammatory activity of betamethasone.
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Calcipotriol has a unique immune modulatory effect on cytokines in psoriatic skin compared to betamethasone.
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The calcipotriol/betamethasone combination effectively inhibits key inflammatory cytokines in T cells, dendritic cells and keratinocytes.