Comparison of the responses of different recombinant fish type I interferons against betanodavirus infection in grouper
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- 作者：Hsiang-Ping Kuoa ; b ; Chia-Ling Chungc ; Yu-Fang Hungc ; Yu-Shen Laid ; Pinwen P. Chiouc ; Ming-Wei Luc ; e ; mingwei@ntou.edu.tw" class="auth_mail" title="E-mail the corresponding author ; Zwe-Ling Konga ; kongzl@mail.ntou.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：Grouper ; Interferons ; Recombinant protein ; Nervous necrosis virus ; Antiviral effect
- 刊名：Fish & Shellfish Immunology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：49
- 期：Complete
- 页码：143-153
- 全文大小：1903 K
文摘
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Four fish type I interferon proteins were successfully expressed and purified.
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An anti-NNV activity of sIFN in GK cells indicates a crosstalk between the heterology.
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Fish IFNs are cytotoxic to GK cells at the higher concentration.
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sIFN and gIFN given through the oral route can protect grouper against NNV.