BMPs in bone regeneration: Less is more effective, a paradigm-shift
详细信息 查看全文
- 作者：Katharina Schmidt-Bleekd ; 1 ; 2 ; Katharina.Schmidt-Bleek@charite.de" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Bettina M. Williea ; b ; 1 ; bwillie@shriners.mcgill.ca" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Philipp Schwabec ; 3 ; Philipp.schwabe@charite.de" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Petra Seemannd ; 4 ; Petra.Seemann@charite.de" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Georg N. Dudad ; georg.duda@charite.de" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae
- 关键词：BMP2 ; Bone healing ; Bone morphogenetic protein ; Regeneration ; Growth factor
- 刊名：Cytokine & Growth Factor Reviews
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：27
- 期：Complete
- 页码：141-148
- 全文大小：1631 K
文摘
- •
This review recalls the history of BMP2 from its discovery to its clinical application.
- •
After more than 125 years BMP2 is still not fully understood: open questions and possibilities are highlighted.
- •
Antagonist-insensitive BMP2 or the interplay of BMP2 and mechano-biology could be future strategies to improve the efficacy and safety of this growth factor in clinical use.