Decreased protein C, protein S, and antithrombin levels are predictive of poor outcome in Gram-negative sepsis caused by Burkholderia pseudomallei

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• 作者：Steven P. LaRosa ; Steven M. Opal ; Barbara Utterback ; Sau Chi Betty Yan ; Jeffrey Helterbr ; Andrew J.H. Simpson ; Wipada Chaowagul ; Nicholas J. White ; Charles J. Fisher ; Jr.
• 关键词：Sepsis ; Melioidosis ; Protein C ; Protein S ; Antithrombin
• 刊名：International Journal of Infectious Diseases
• 出版年：2006
• 出版时间：January 2006
• 年：2006
• 卷：10
• 期：1
• 页码：25-31
• 全文大小：206 K

文摘

Acute septicemic melioidosis is associated with systemic release of endotoxin and the proinflammatory cytokines tumor necrosis factor (TNF)-alpha, interleukin-1, and interleukin-6. Excessive release of these cytokines may lead to endothelial injury, depletion of naturally occurring endothelial modulators, microvascular thrombosis, organ failure, and death.

Method

Plasma samples drawn at baseline and after initial antimicrobial therapy in 30 patients with suspected acute severe melioidosis were assayed for D-dimer levels, protein C and protein S antigen levels, and antithrombin functional activities.

Results

Both baseline and continued deficiencies of protein C, protein S, and antithrombin were statistically associated with a poor outcome by logistic regression. Baseline D-dimer levels were significantly higher in fatal cases than survivors and correlated inversely with protein C and antithrombin, suggesting both increased fibrin deposition and fibrinolysis.

Conclusion

The inflammatory response to systemic Burkholderia pseudomallei infection leads to depletion of the natural endothelial modulators protein C, protein S, and antithrombin. Both baseline and continued deficiency of these endothelial modulators is predictive of poor outcome in melioidosis.