Neonatal lipopolysaccharide treatment alters hippocampal neuroinflammation, microglia morphology and anxiety-like behavior in rats selectively bred for an infantile trait

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• 作者：Lauren D. Claypoole ; Betty Zimmerberg ; Lauren L. Williamson ; ^{07llw@williams.edu}
• 关键词：Neonatal inflammation ; Development ; Anxiety ; Microglia
• 刊名：Brain, Behavior, and Immunity
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：59
• 期：Complete
• 页码：135-146
• 全文大小：1249 K
• 卷排序：59

文摘

Neonatal immune challenge increases anxiety-like behavior in a low-anxiety rat line. Neonatal immune challenge reduces anxiety-like behavior in a high-anxiety rat line. Neonatal immune challenge alters peripheral inflammation in a phenotypic-dependent manner. Sex and phenotype interact after neonatal LPS to alter anxiety-like behavior.