Influence of genetic taste sensitivity to 6-n-propylthiouracil (PROP), dietary restraint and disinhibition on body mass index in middle-aged women

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• 作者：Tepper ; Beverly J. ; Ullrich ; Natalia V.
• 关键词：6-n-Propylthiouracil ; Taste ; Body mass index ; Obesity
• 刊名：Physiology and Behavior
• 出版年：2002
• 出版时间：March, 2002
• 年：2002
• 卷：75
• 期：3
• 页码：305-312
• 全文大小：150 K

文摘

A previous study from our laboratory reported a small, inverse association between taste sensitivity to 6-n-propylthiouracil (PROP) and body mass index (BMI) among lean, young-adult males. Weaknesses in study design precluded making this same observation in females. To overcome these shortcomings, the present study investigated this relationship in older, heavier women characterized by dietary restraint and disinhibition. We tested the hypothesis that lower taste sensitivity to PROP would be associated with higher BMI but that high dietary restraint would mask this association. Thus, no relationship between taster status and BMI was expected in those with high dietary restraint. Eighty-six, middle-aged women (39.0±1.0 years) with a mean BMI of 27.4±0.8 participated. They were classified as PROP nontasters (n