Based on statistical analysis, optimal conditions for the production of geranyl butyrate by selected, immobilized lipase in the batch system are recommended as: temperature at 25-30 ¡ãC, water concentration at 3.6 % (v/v) and acid/alcohol molar ratio at 2.5. A set of optimal conditions for the ester synthesis in a fluidized bed reactor system has also been determined, specifically, flow rate at 10 mL min?, temperature at 35 ¡ãC, water concentration at 2 % (v/v), substrate concentration at 0.1 M and acid/alcohol ratio at 2.0. Implementation of the optimized parameters in a batch system and in a fluidized bed reactor enabled production of target ester with high molar conversion, at > 99.9 % for 48 h in the batch process, and 78.9 % for 10 h in fluidized bed reactor. Although when assayed at their optimal conditions, lower molar conversion was achieved in the fluidized bed reactor system compared to the batch system, the volumetric productivity in fluidized bed reactor was more than five fold higher than that obtained in the batch system.