Syntheses and photodynamic activity of some glucose-conjugated BODIPY dyes
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- 作者：Neelam Shivran1 ; Mrityunjay Tyagi1 ; Soumyaditya Mula1 ; Pooja Gupta ; Bhaskar Saha ; Birija S. Patro ; Subrata Chattopadhyay ; schatt@barc.gov.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：Apoptosis ; BODIPY dyes ; Lung cancer ; Photodynamic property
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：21 October 2016
- 年：2016
- 卷：122
- 期：Complete
- 页码：352-365
- 全文大小：2675 K
文摘
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Formulation of a BODIPY dye, possessing a glycosylated styryl moiety at the C-3 position as a potent photodynamic agent.
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The BODIPY was phototoxic to human lung cancer A549 cell line, inducing caspase-8/caspase-3-mediated apoptosis.
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The BODIPY was non-toxic to normal human lung cell lines, and was devoid of any dark cytotoxicity.