Amantadine resistance among highly pathogenic avian influenza viruses (H5N1) isolated from India
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- 作者：Aron Jacoba ; Richa Sooda ; richa.bhatia0609@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Kh. Victoria Chanua ; Sandeep Bhatiaa ; Rekha Khandiaa ; A.K. Pateriyaa ; S. Nagarajana ; U. Dimrib ; D.D. Kulkarnia
- 关键词：Avian influenza ; Amantadine ; Antiviral resistance ; Matrix
- 刊名：Microbial Pathogenesis
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：91
- 期：Complete
- 页码：35-40
- 全文大小：365 K
文摘
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Resistance to amantadine was identified among four H5N1 viruses isolated in India.
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Two viruses with S31N mutation had higher EC50 of amantadine than the two with V27A.
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Resistant viruses replicated in vitro at peak non-toxic concentration of the drug.
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Resistance was also shown by HA after in vitro growth of viruses with amantadine.