Huntingtin interacting protein HYPK is a negative regulator of heat shock response and is downregulated in models of Huntington's Disease
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- 作者：Srijit Dasa ; mail2srijit@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Nitai Pada Bhattacharyyaa ; b ; nitai_sinp@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; director.bmgc@nibmg.ac.in" class="auth_mail" title="E-mail the corresponding author ; nitai.bhattacharyya@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：AcH4 ; acetylated histone H4 ; ChIP ; chromatin immunoprecipitation ; HD ; Huntington's Disease ; HTT ; Huntingtin ; HSE ; heat shock element ; HSF1 ; heat shock factor 1 ; HSPs ; heat shock proteins ; HSR ; heat shock response ; HYPK ; Huntingtin Yeast Partner K ; qRT-PCR ; quantitative real-time PCR.
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：1 May 2016
- 年：2016
- 卷：343
- 期：2
- 页码：107-117
- 全文大小：1994 K
文摘
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HYPK inhibits heat shock response.
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HYPK regulates its own expression.
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HYPK is downregulated in Huntington's Disease models.
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HSF1 occupancy in HYPK promoter is altered in HD cell model.
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Mutant huntingtin inhibits heat shock response.