Regulation of mitochondrial morphology and cell cycle by microRNA-214 targeting Mitofusin2
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- 作者：Sudha Buchaa ; Debashis Mukhopadhyayb ; Nitai Pada Bhattacharyyaa ; c ; nitai_sinp@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; director.bmgc@nibmg.ac.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：MicroRNA-214 ; Mitofusin2 ; Cell cycle ; Mitochondria ; Huntington's disease ; Huntingtin
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2015
- 出版时间：2 October 2015
- 年：2015
- 卷：465
- 期：4
- 页码：797-802
- 全文大小：1247 K
文摘
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miR-214 decreases the mRNA expression of HTT co-expressed genes which are predicted to be targeted by it.
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miR-214 down regulates the expression of MFN2.
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Expression of MFN2 is down regulated in STHdhQ111/111 cells compared to STHdhQ7/7 cells.
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miR-214 alters the mitochondrial morphology in STHdhQ7/7 cells via MFN2.
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miR-214 alters the cell cycle distribution of the STHdhQ7/7 cells via MFN2.