MiR-17-92 represses PTPROt and PP2A phosphatases and amplifies tonic BCR signaling in DLBCL cells

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• 作者：Ewa Jablonska^a ; Patryk Gorniak^a ; Maciej Szydlowski^a ; Tomasz Sewastianik^a ; Emilia Bialopiotrowicz^a ; Anna Polak^a ; Krzysztof Warzocha^b ; Przemyslaw Juszczynski^a ; ^{pjuszczynski@ihit.waw.pl}
• 刊名：Experimental Hematology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：46
• 期：Complete
• 页码：56-61.e1
• 全文大小：1088 K
• 卷排序：46

文摘

miR-17-92 represses expression of PTPROt and PP2A regulatory subunits in DLBCL cells. miR-17-92 amplifies BCR-dependent SYK and AKT activity in DLBCL. miR-17-92 decreases sensitivity of DLBCL cells to SYK inhibition.