Distorted tetrahedral bis-(N,S) bidentate Schiff base complexes of Ni(II), Cu(II) and Zn(II): Synthesis, characterization and biological studies

详细信息    查看全文

• 作者：Nanjan Nanjundan^a ; Ramaswamy Narayanasamy^a ; ^{narayanasamycit@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Steven Geib^b ; Krishnaswamy Velmurugan^c ; Raju Nandhakumar^c ; Manickam Dakshinamoorthi Balakumaran^d ; Pudupalayam Thangavelu Kalaichelvan^d
• 关键词：Schiff base complexes ; X-ray/DFT study ; DNA/BSA binding activities ; Catalytic efficacy ; In vitro anticancer activities
• 刊名：Polyhedron
• 出版年：2016
• 出版时间：28 May 2016
• 年：2016
• 卷：110
• 期：Complete
• 页码：203-220
• 全文大小：4273 K

文摘

Transition metal complexes of acetophenone-S-allyldithiocarbazate [H-(Ap-sadtc)] of the general formula [M-(Ap-sadtc)₂] (Ni²⁺, Cu²⁺, Zn²⁺) (1–3) were synthesized and characterized by elemental analysis, UV–Vis, FT-IR, ¹H NMR, ¹³C NMR and mass spectroscopy. The molecular structures of the ligand and its complexes 1–3 were confirmed by both theoretical as well as experimental methods. The interactions of the complexes with biomolecules, such as calf thymus DNA (CT-DNA) and bovine serum albumin (BSA), were explored using absorption and emission spectral techniques. All the complexes synthesized were found to be most promising due to their large binding affinity towards different bio-macromolecules and higher K_cat values in catechol oxidation (3,5-DTBC)/phosphate hydrolysis (4-NPP) reactions. The in vitro anticancer activities using MTT and a morphological staining assay indicate that the complexes are active against the (Hela) cervical cancer cell line, which is consistent with our above mentioned hypothesis.