Calixarene-derived chiral tertiary amine-thiourea organocatalyzed asymmetric Michael additions of acetyl acetone and dimethyl malonate to nitroolefins

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• 作者：Mustafa Durmaz ; ^{mdurmaz@konya.edu.tr" class="auth_mail" title="E-mail the corresponding author} ; Aysun Tataroglu ; Horu Yilmaz ; Abdulkadir Sirit
• 刊名：Tetrahedron: Asymmetry
• 出版年：2016
• 出版时间：15 February 2016
• 年：2016
• 卷：27
• 期：2-3
• 页码：148-156
• 全文大小：836 K

文摘

Novel bifunctional chiral thiourea-tertiary amines bearing a calix[4]arene scaffold were synthesized and applied in catalytic asymmetric Michael addition of acetyl acetone and dimethyl malonate to nitroolefins. The corresponding adducts were obtained in excellent yields (up to 99%) and with high enantioselectivities (up to 94% ee).