Tertiary amino thiourea-catalyzed asymmetric cross aldol reaction of aryl methyl ketones with aryl trifluoromethyl ketones

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• 作者：Lé ; opold Mpaka Lutete ; Takashi Miyamoto ; Tetsuya Ikemoto ; ^{ikemotot2@sc.sumitomo-chem.co.jp" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Aldol reaction ; Thiourea ; Bifunctional catalyst ; Organocatalysis ; Trifluoromethyl ketones
• 刊名：Tetrahedron Letters
• 出版年：2016
• 出版时间：16 March 2016
• 年：2016
• 卷：57
• 期：11
• 页码：1220-1223
• 全文大小：1446 K

文摘

An enantioselective aldol reaction of aryl methyl ketones with aryl trifluoromethyl ketones catalyzed by tertiary amino thiourea has been established. Under mild conditions, the corresponding β-trifluoromethyl-β-hydroxy ketone products were obtained with up to 89% ee.