Pharmacological and Environmental Determinants of Relapse to Cocaine-Seeking Behavior

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• 作者：Spealman ; R.D. ; Barrett-Larimore ; R.L. ; et. al.
• 关键词：Relapse ; Reinstatement ; Drug cues ; Drug priming ; Stress ; Cocaine ; Dopamine agonists and antagonists ; D₁- and D₂-like receptor mechanisms ; Medications development
• 刊名：Pharmacology Biochemistry and Behavior
• 出版年：1999
• 出版时间：October, 1999
• 年：1999
• 卷：64
• 期：2
• 页码：327-336
• 全文大小：316 K

文摘

Animal models have been developed that simulate relevant features of relapse to cocaine-seeking behavior in humans. These models have provided valuable information about pharmacological and environmental factors that precipitate reinstatement of extinguished cocaine-seeking in rats and monkeys, as well as new insights about potential pharmacotherapies for relapse prevention. Reinstatement of cocaine-seeking behavior in animals can be induced by cocaine priming or by cocaine-paired environmental stimuli; however, maximum reinstatement of drug-seeking appears to be induced when cocaine priming and cocaine-paired stimuli are combined. Drugs that share cocaine's indirect dopamine agonist properties or that act as direct agonists at D₂-like dopamine receptors also induce reinstatement of cocaine-seeking behavior, whereas with some exceptions (e.g., caffeine, morphine) drugs from other pharmacological classes do not. D₁-like receptor agonists block rather than mimic the priming effects of cocaine, suggesting different roles for D₁- and D₂-like receptor mechanisms in cocaine relapse. Although considerable overlap exists, drugs that exhibit cocaine-like discriminative stimulus and/or reinforcing effects in other situations do not invariably induce cocaine-like reinstatement of drug-seeking and vice versa, implying that these effects are not simply different behavioral expressions of a unitary neurobiological process. Finally, recent findings with D₁-like receptor agonists, partial agonists, and antagonists suggest that some of these drugs may be viable candidates for development as antirelapse pharmacotherapies. Publisher: Elsevier Science Language of Publication: English Item Identifier: S0091-3057(99)00049-0 Publication Type: Article ISSN: 0091-3057 Cited by:

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Footnotes:

1. Present address: Department of Psychology, Morgan State University, Jenkins Behavioral Science Building, Baltimore, MD 21251