Novel use of superdisintegrants as viscosity enhancing agents in biocompatible polymer films containing griseofulvin nanoparticles
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- 作者：Ramana Susarla ; Afolawemi Afolabi ; Darshan Patel ; Ecevit Bilgili ; Rajesh N. Davé ; ; dave@njit.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Nanosuspensions ; Pharmaceutical films ; Superdisintegrants ; Gums ; Viscosity enhancing agents ; Poorly water soluble drugs
- 刊名：Powder Technology
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：285
- 期：Complete
- 页码：25-33
- 全文大小：1458 K
文摘
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Superdisintegrants are used as viscosity enhancing agents (VEAs) in drug loaded films.
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Their use prevented aggregation and improved drug nanoparticle stability in films.
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This led to high drug content uniformity and nanoparticle surface area retention.
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Superdisintegrants led to faster drug dissolution without increase in film strength.
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Superdisintegrants exhibited superior performance over traditional VEAs.