Behavioural deficits associated with maternal immune activation in the rat model of schizophrenia

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• 作者：Amy R. Wolff ; Kirsten R. Cheyne ; David K. Bilkey&#xA0 ; ; &#xA0 ; ^{dbilkey@psy.otago.ac.nz}
• 关键词：Immune ; Context ; Memory ; Reversal ; Schizophrenia ; Rat
• 刊名：Behavioural Brain Research
• 出版年：2011
• 出版时间：20 November 2011
• 年：2011
• 卷：225
• 期：1
• 页码：382-387
• 全文大小：349 K

文摘

Schizophrenia is associated with changes in memory and contextual processing. As maternal infection is a risk factor in schizophrenia we tested for these impairments in a maternal immune activation (MIA) animal model. MIA rats displayed impaired object recognition memory, despite intact object discrimination, and a reduced reinstatement of rearing in response to a contextual manipulation. These results link MIA to contextual impairments in schizophrenia, possibly through changes in hippocampal function.