Altered arginine metabolism in the hippocampus and prefrontal cortex of maternal immune activation rat offspring

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• 作者：Yu Jing ; Hu Zhang ; Amy R. Wolff ; David K. Bilkey ; Ping Liu
• 关键词：ADC ; arginine decarboxylase ; ASL ; argininosuccinate lyase ; ASS ; argininosuccinate synthetase ; DG ; dentate gyrus ; GABA ; ¦Ã-aminobutyric acid ; MIA ; maternal immune activation ; NO ; nitric oxide ; NOS ; nitric oxide synthase ; PFC ; prefrontal cortex ; poly I ; C ; p
• 刊名：Schizophrenia Research
• 出版年：2013
• 出版时间：August, 2013
• 年：2013
• 卷：148
• 期：1-3
• 页码：151-156
• 全文大小：627 K

文摘

Altered arginine metabolism has been implicated in the pathogenesis of schizophrenia. The present study measured the levels of L-arginine and its downstream metabolites in the sub-regions of the hippocampus, prefrontal cortex and cerebellum in adult rats that had been exposed to maternal immune activation (MIA; a risk factor for schizophrenia). MIA significantly increased L-arginine, L-ornithine and putrescine levels and decreased agmatine levels in the hippocampus and prefrontal cortex in a region-specific manner. Correlational analysis revealed a significant neurochemical-behavioural correlation. Cluster analyses showed that L-arginine and its main metabolites formed distinct groups, which changed as a function of MIA. These results demonstrate, for the first time, that MIA leads to altered arginine metabolism in the hippocampus and prefrontal cortex of the adult offspring.