Study on the interaction between curcumin and CopC by spectroscopic and docking methods

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• 作者：Zhen Song^a ; Wen Yuan^a ; Ruitao Zhu^a ; Song Wang^a ; Caifeng Zhang^a ; ^c ; Binsheng Yang^b ; ^{yangbs@sxu.edu.cn}
• 关键词：CopC ; Curcumin ; Fluorescence
• 刊名：International Journal of Biological Macromolecules
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：96
• 期：Complete
• 页码：192-199
• 全文大小：1704 K
• 卷排序：96

文摘

1:1 complex formed from curcumin and CopC or Cu2+-CopC and curcumin was investigated. The effects of curcumin on the CopC stability were evaluated by FTIR, CD and chemical denaturation. The mainly acting force between CopC and curcumin was inferred. The distance between the unique Trp in CopC and curcumin was measured. The mainly acting force, the distance, the binding site of curcumin in CopC was vivid simulated by docking studies.